One observational study found an association between prenatal substance exposure and mental health in children aged 10 to 12 years, but controlling for environment and genetics could eliminate many associations. found.
Qiang Luo and colleagues analyzed longitudinal data from nearly 10,000 participants in the Adolescent Brain Cognitive Development Cohort and found that mothers' self-reported prenatal exposure to caffeine, alcohol, tobacco, and marijuana , we investigated the association with mental health outcomes from 10 to 12 years of age. The authors found a number of associations between prenatal exposure to the substances studied and neurobehavioral problems, many of which the authors attribute to environmental and genetic factors. It decreased when controlled.
Environmental risk factors are assessed using indicators such as planned birth, vitamin intake during pregnancy, breastfeeding duration, preterm birth, parental age at birth, parental partnership, parental education level, family income, and neighborhood safety measures. Understood. Genetic background was established by family history of mental disorders and polygenic risk score. Even after accounting for genetics and environment, no significant association remained between prenatal tobacco smoke exposure and outcomes at ages 10 to 12 years. However, prenatal alcohol exposure was significantly associated with sleep problems and mental health problems at ages 10 to 12, even after controlling for environment and genetics.
Additionally, the authors found that, in contrast to previous reports that prenatal alcohol exposure was correlated with smaller cerebral gray matter volume later in life, gray matter volume in children exposed to alcohol in utero was significantly lower. was found to be larger. According to the authors, the increase in gray matter volume, accompanied by decreased function in other brain regions, may reflect a compensatory response in some brain regions to cope with the effects of maternal alcohol use.
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Reference magazines:
Goo, Z. other. (2023). Prenatal substance exposure and child health: Understanding the role of environmental factors, genetics, and brain development. PNAS Nexus. doi.org/10.1093/pnasnexus/pgae003.
