In a breakthrough development, scientists are on the verge of creating a pill that can simulate the health benefits traditionally derived from exercise. This new approach aims to combat muscle deterioration and a variety of diseases such as heart disease and neurodegenerative diseases.
The research will be presented by experts from Washington University in St. Louis (WUSTL) at the Spring 2024 meeting of the American Chemical Society (ACS). Featuring approximately 12,000 scientific presentations, this hybrid event will be held both virtually and in-person from March 17-21.
The irreplaceable value of physical activity
WUSTL professor of anesthesiology and lead researcher Bahaa Elgendy emphasized the irreplaceable value of physical activity, but acknowledged the need for alternatives in certain situations.
“Nothing can replace exercise. Exercise is important at all levels. If you can exercise, you should do it. But there are often times when you need an alternative. [for example in older people of those suffering from various diseases.]”
The researchers' findings focus on compounds that initiate the metabolic changes seen after exercise, specifically targeting estrogen-related receptors (ERRs), which are crucial for improving muscle cell metabolism, growth, and performance.
After 10 years of research, they discovered a promising compound, SLU-PP-332, that activates all three forms of ERR, including ERRα, a key regulator of exercise-induced stress adaptation in muscle. developed. Initial experiments in mice demonstrated that the compound not only increases fatigue-resistant muscle fibers, but also significantly improves endurance.
Improved simulation of exercise effects
To create SLU-PP-332, scientists carefully analyzed the structure of ERR and its activation mechanism. Based on this foundation, they designed new molecules that form stronger bonds with these receptors, offering enhanced efficacy compared to SLU-PP-332, along with increased stability and reduced toxicity risk. There is likely to be.
The efficacy of SLU-PP-332 and its successors was determined by examining RNA levels reflecting gene expression in rat cardiomyocytes. The results showed a more pronounced simulation of kinetic effects by the new compound.
Preliminary studies using SLU-PP-332 show that targeting ERR holds promise for treating obesity, heart failure, and age-related decline in kidney function.
Additionally, ERR activity may attenuate brain damage associated with Alzheimer's disease and other neurodegenerative diseases. Although SLU-PP-332 does not enter the brain, several new compounds are being designed with this ability in mind.
Physiological benefits of physical activity
Ergendi expressed optimism about the potential for activating ERR to produce a variety of health benefits. The research team, in collaboration with the start-up company they co-founded, Pelagos Pharmaceuticals, plans to further test these compounds in animal models to explore potential applications in the treatment of neurodegenerative diseases.
This innovative approach could pave the way for innovative treatments that provide the physiological benefits of exercise without the need for physical exercise.
health benefits of exercise
Exercise has a wide range of health benefits that positively impact both your body and mind. Here's a summary of the main benefits:
cardiovascular health
Regular physical activity strengthens the heart, improves circulation, and reduces the risk of heart disease and stroke.
weight management
Exercise helps you maintain a healthy weight by burning calories and increasing your metabolism.
strengthens muscles and bones
Activities such as weightlifting promote muscle building when combined with adequate protein intake. Exercise can also help increase bone density and reduce the risk of age-related osteoporosis.
mental health
Physical activity is known to reduce symptoms of depression and anxiety. Endorphins are released that create a feeling of happiness and euphoria.
cognitive function
Regular physical activity helps keep your thinking, learning, and judgment skills sharp as you age. It can also reduce your risk of developing diseases such as Alzheimer's disease.
improve sleep
Exercise will help you fall asleep faster and sleep deeper, as long as it's not too close to bedtime.
extend lifespan
Regular physical activity leads to a longer lifespan. Even moderate amounts of exercise can make a big difference.
immune system
Regular, moderate exercise boosts your immune system and helps fight infections.
Mobility and flexibility
Exercise helps maintain physical function and prevents age-related declines in mobility and flexibility.
Quality of life
Regular physical activity can improve your overall quality of life by strengthening your ability to perform daily activities, increasing your energy levels, and improving your overall mood.
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