Self-blood tests show potential for checking heart health

Researchers at Murdoch University's Australian National Phenome Center have conducted an autologous blood test that could revolutionize the landscape of cardiovascular risk assessment.

Tests typically performed to detect heart disease or cardiovascular risk are complex and require sampling of venous blood, usually performed by a doctor, nurse, or phlebotomist.

But Dr. Nathan Lawler and Ph.D. candidate Jayden Roberts have perfected a method to measure large collections of lipoproteins in pinprick blood samples that can be done remotely without medical supervision. I let it happen.

Their paper “Rapid and Self-Administrable Capillary Blood Microsampling Demonstrates Statistical Equivalence with Standard Venous Collections in NMR-Based Lipoprotein Analysis” has been published in the journal analytical chemistry.

Dr Lawlor and Roberts' new tests, in collaboration with ANPC Director Professor Jeremy Nicholson, include metabolic phenotyping using capillary microsampling and nuclear magnetic resonance spectroscopy, which involves the transport of cholesterol and lipids. Accurately measures 112 lipoproteins.

Metabolic phenotyping captures an integrated profile of an individual's biological state and reflects gene-environment interactions, particularly in response to external stressors.

Detailed insights into cardiovascular health, including established HDL-C, LDL-C, VLDL-C, diastolic parameters such as triglycerides and apolipoproteins, using only a small self-administered fingertip sample You can now access it. B100/apolipoprotein A1 ratio (ABA1).

“This will revolutionize the landscape of cardiovascular risk assessment by enabling rapid, non-invasive lipoprotein analysis,” Dr. Lawler said. “This innovation has the potential to enable individuals to actively monitor their health status.”

Importantly, Roberts said, the test can be performed at a pharmacy or community health center, making it easy to get an accurate and comprehensive cardiovascular health assessment.

“ANPC plans to further simplify blood collection, which will allow testing to be made more widely available in remote areas and to people without access,” he said.

Professor Nicholson said the ability to easily monitor lipoprotein levels meant people could take active steps to reduce cardiovascular risk factors by adopting a healthier lifestyle. Said to mean. “This improves health status and reduces the incidence of cardiovascular disease,” he said. “This is a very practical advance based on the highest quality international science applied to clinical translation.”